Until then, I would suggest that it is better not to uncheck "Apply to trusted sites too", but rather to click on the placeholder (the red NoScript block-logo) for individual videos that you want to watch, e. g., at YouTube. Otherwise, you are allowing whatever random videos are playing upon each visit, and everything else as well. Better to choose a few than to allow a million.
That's exactly why I've enabled "Apply to trusted site too" in the first place.
I'd also ask you to reconsider allowing JavaScript globally "for compatibility and convenience reasons".
What compatibility? Please name a URL or situation with which NoScript cannot be configured so as to be compatible.
I've used NoScript in it's default state for years now. Many sites do not work correctly without javascript, and after a while surfing, NoScript becomes quite annoying. I also go to lot of one-click file hosters (Rapidshare, Megaupload, etc.), and most of them requires javascript to be enabled (sometimes even whitelisting the site doesn't work, because other associated sites are blocked).
An example is this bookmarklet called PageZipper, which doesn't work to its full potential with NoScript. It's supposed to load multiple pages when scrolling down, but NoScript only allows it to load 2.
As for convenience, please read the NoScript Quick Start Guide, and peruse the NoScript FAQ. I think you'll find that you'll have your favorite sites configured permanently in a relatively brief period of time. And isn't having a virus, spyware, or other malware, and the damage they can do (passwords stolen, bank account drained, identity theft) a bit more inconvenient?
Believe me, I've configured it extensively, but as I explore more of the web, it just becomes a nuisance.
Lastly I've compiled a list of my security setup, after reading it, you tell me whether I need NoScript or not.
Network Protection
Untangle
Router with SP1 firewall and Comodo Secure DNS.
Real-time Protection
Comodo Internet Security (Firewall+HIPS)
Avira Free
WinPatrol Free
Passive Protection
Windows 7 UAC (no prompts, thanks to UACTweak)
Disallowed-by-default Software Restriction Policy
SpywareBlaster
On-demand Scanning
A-squared Free
Comodo AV
Malwarebytes' Anti-malware
Prevx CSI
Returnil Virus Guard
Sophos Anti-Rootkit
SUPERAntispyware
Firefox Add-ons
Adblock Plus
NoScript (custom Global allow)
LinkExtend
Others
HiJackThis (+
http://www.hijackthis.de/)
VirusTotalUploader
Software Updates
RSS Feeds: kaldata.net, Freeware Guide, FileHippo.com, Softpedia
KC Softwares SUMo
Secunia PSI
Update Notifier
System Virtualization
Returnil Home Free
System Backup
Windows 7 System Image