NoScript 10.1.8.9rc6
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NoScript
100 requests, 7.82 MB / 4.72 MB transferred, Finish 4.23 s, DOMContentLoaded 1.10 s
Safe Mode
110 requests, 8.04 MB / 4.79 MB transferred, Finish 5.98 s, DOMContentLoaded 1.29 s, Load 4.70 s
I actually wasn't expecting that, that it would be so close.
Am actually surprised that it is.
Safe Mode has that Load figure that was not given with NoScript enabled.
Though... that looks like it is going to be because of, 
https://forums.informaction.com/viewtop ... 929#p97929.
To me, those numbers are within tolerance, even the 1 s Finish time...
Though... I guess it is true.
Now, can't say what those numbers particularly mean?
Finish? Just what is finished?
And how does Finish differ from "Load"?
Load is not determinable, presently - with NoScript enabled.
So excluding Load, I'll say with or without NoScript, page loading time is within tolerances.
Depending on what "Load" means, & once we're able to see its' figure (in a meaningful way) with NoScript enabled, for now, I've got to say, close enough.
Seat of the pants, gives me the impression that Safe Mode is "cleaner".
Though the numbers I've put together, so far, say otherwise.
Cleared; Cookies, Cache, & Offline Website Data, between runs, &/or restarted FF between timings (from within Browser Console -> Network).
Using that methodology, for better or worse, so maybe the method if flawed.
Looking at "performance".
Safe Mode on the left, NoScript on the right.
I would clear cache..., then force reload the page, a few times in succession.
With NoScript enabled, I'd say higher CPU & longer duration.
So all in all, close enough, but with conflicting numbers or counter to expected.
?
Looking at "performance".
Ah, you're going to have to take that with a grain...
The screenshot, the CPU, Mem, I/O, is only going to be of the parent firefox.exe process.
I initially thought it was showing, I assumed it was showing an accumulation of the entire "multi-process" firefox process, but it is not.
Though between Safe Mode & starting Normally, FF 
does use more RAM.
In my Profile, as it is, (& with NoScript, & now Load Time, being my only extensions), FF ram changes from ~220 MB to ~330 MB.
(Now, extensions are not the only things that differ when you run in 
Safe Mode.)