If I saw the browser making a connection to some random domain like cksks.soie.net, then I would have no idea what it was, but I would be pretty sure it was nothing to do with NoScript.
Did you read the OP? It was noscript and another addon.
So after updating firefox is making connections to Google, Amazon, Edgecast and GoDaddy even in safe mode with no tabs loaded. How do I stop this?
184.108.40.206 Google Inc.
220.127.116.11 Amazon Technologies Inc.
18.104.22.168 EdgeCast Networks, Inc.
22.214.171.124 Amazon Technologies Inc.
126.96.36.199 Network Solutions, LLC
188.8.131.52 Google Inc.
184.108.40.206 GoDaddy.com, LLC