If I saw the browser making a connection to some random domain like cksks.soie.net, then I would have no idea what it was, but I would be pretty sure it was nothing to do with NoScript.
Did you read the OP? It was noscript and another addon.
So after updating firefox is making connections to Google, Amazon, Edgecast and GoDaddy even in safe mode with no tabs loaded. How do I stop this?
188.8.131.52 Google Inc.
184.108.40.206 Amazon Technologies Inc.
220.127.116.11 EdgeCast Networks, Inc.
18.104.22.168 Amazon Technologies Inc.
22.214.171.124 Network Solutions, LLC
126.96.36.199 Google Inc.
188.8.131.52 GoDaddy.com, LLC